IPVI - Intestinal Parasitic and Vaginal Infection Pregnancy Outcome Study


A joint research collaborative study between University of Pittsburgh and SHARE INDIA- MIMS is approved by the Helath Screening Committee of ICMR, GoI.

Investigators:

SHARE INDIA ,  MediCiti Institute of Medical Sciences.

•    Kalpana Betha, MD, Associate Professor
•    K. Balasubramanian, PhD, Associate Director of Research
•    Haripriya Vedantham, MD, Assistant Professor, MIMS.
•    Govind Narsingrao K. MD, Associate Professor, MIMS.
•    P.S. Reddy, MD, Professor and Chairman.

University of Pittsburgh

•    Catherine L. Haggerty, PhD, M.P.H, Assistant Professor
•    Clareann H. Bunker, PhD, Associate Professor
•    Gong Tang, PhD, Assistant Professor
•    Peter Veldkamp, MD, Associate Professor of Medicine. 
•    Bernard Macatangay, MD, Instructor of Medicine. 

Other Foreign Consultants:

•    Jorgen Jensen, MD, PhD, D.Med.Sci, Consultant, Statens Serum Institute, Copenhagen S, Denmark. 
•    Lisette Van Lieshout, PhD, Associate Professor of Clinical Parasitology , Leiden University Medical Center, The Netherlands. 
•    Jaco Verweij, PhD, Parasitologist at Leiden University Medical Center, The Netherlands.

Objectives:

The Intestinal Parasitic and Vaginal Infection Pregnancy Outcome Study (IPVI) is designed to enroll 2,010 couples aged 15-35 in selected villages in the Medchal Mandal region of Telangana, India to meet the following objectives.

  1. To determine population-based prevalence of parasitic infection in rural Telangana and to characterize the burden of infection according to specific parasite types, both protozoa and helminthes.
  2. To determine whether maternal parasitic infection is associated with adverse pregnancy outcomes.
  3. To compare the risks of adverse pregnancy outcomes between women with BV or infected with BV-associated microorganisms (Bacterial Vaginosis Associated Bacteria 1 (BVAB1), BVAB2, BVAB3, Gardnerella vaginalis, Atopobium vaginae, Eggerthella-like bacterium, Leptotrichia spp., Megasphaera phylotype 1, Megasphaera phylotype 2, BVAB-TM7, Mobiluncus curtisii, M. mulieris, Peptoniphilus sp. type 1 Peptoniphilus lacrimalis, and Prevotella G1) or Mycoplasma genitalium and those without infection.
  4. To determine the concordance of BV-associated microorganisms and Mycoplasma genitalium measured between sexual partners.
  5. To determine the concordance of BV-associated microorganisms among stool and vaginal specimens obtained from pregnant women.